Biofilm formation of Escherichia coli title as a trigger of catheter-associated urinary tract infections

The widespread use in urological practice of biological and artificial materials, on the surface which bacterial biofilms form, increases risk pathogen persistence human body. Nowaday, there is an acute problem catheter-associated urinary tract infections (САUTI), are most commonly caused by uropathogenic Escherichia coli (UPEC) strains, either monoculture as part polymicrobial associations with fecal microbiota. Bacterial adhesion colonization catheter determined, one hand, nature polymeric material, and, other a set fimbrial afimbrial adhesins, well outer membrane proteins pathogens. Attachment bacteria to cells biotopes also mediated various adhesins important pathogenesis CAUTI. Optimal conditions for horizontal gene transfer (HGT), numerous virulence- associated antibiotic resistance factors through conjugation mobilization created adhered microbial communities. At same time, conjugative can introduce additional dynamics into biofilm formation due increased expression sex pili needed plasmid transfer. As implementation scientific projects, genetic profiles strains E. were studied, their relationship was assessed, considering type effect some antibacterial drugs urethral catheters determined. In addition, frequency F-plasmid transmission plankton studied depending properties recipient strains: phylogenetic group, biofilm-forming ability, lysogeny, bacteriocin production, sensitivity. data obtained will contribute better understanding mechanisms intraspecific interaction biofilms, allow us identify features patterns UPEC